News >> Browse Articles >> Health

+1

Wanted: Volunteers For Free Week-Long Holidays in Mexico

Wanted: Volunteers For Free Week-Long Holidays in Mexico

Will be expected to spend days in hotel bathroom with very upset stomach

The Independent

December 29, 2009

By Jeremy Laurance

Fancy a free holiday in Mexico, all expenses paid? Or perhaps Guatemala appeals? Flights and hotel accommodation up to the value of £1,400 are on offer for 900 volunteers who are prepared to test a remedy for one of the most common holiday afflictions – travellers’ diarrhoea.

In a novel twist on the usual drug company trial in which volunteers are paid to attend a clinic and be injected with a new agent to see how they react, the “Trek Study” sponsored by Intercell, a US vaccine manufacturer, is instead despatching willing backpackers to a part of the world where the bacteria that cause runny tummies are rife.

Volunteers will stay in three-star hotels but can choose where they go and what they eat and drink, provided they do not stray more than three hours’ travelling time from one of the centres in Mexico or Guatemala where they are required to attend for blood tests and to provide stool samples if they develop an upset stomach.

A second study is planned of travellers to India, for which recruitment has not yet started.

Thomas Lingelbach, chief executive of Intercell, said the company hoped to obtain a global licence for the product. “We need to show the vaccine is effective in different geographical settings, as the bacteria that cause diarrhoea are different in different regions. If we can show broad coverage against travellers’ diarrhoea we estimate we could get peak sales of 500m a year in five to 10 years.”

Drug trials were popular with students as a way of boosting meagre bank balances until the 2006 catastrophe in which six volunteers nearly died at Northwick Park Hospital in north-west London – and one was described by his girlfriend as looking “like the Elephant Man” – after a trial of a monoclonal antibody, TGN1412, went disastrously wrong.

That was a Phase 1 trial – the first time the drug had been tested in humans. The travellers’ diarrhoea vaccine has already been tested on humans and an initial study with 170 American volunteers, who also travelled to Mexico and Guatemala, was encouraging. Half were given the vaccine and half a placebo, and results published in The Lancet medical journal last year showed it reduced the incidence of diarrhoea by 75 per cent.

Travellers’ diarrhoea lasts on average for four to five days, involves 18 trips to the toilet and leaves sufferers dehydrated and debilitated. It blights millions of holidays every year with stomach cramps, nausea and vomiting. In The Lancet study, 21 per cent of those given the placebo had a moderate to severe attack of diarrhoea compared with 5 per cent of those who received the vaccine.

For the new study, volunteers aged 18 to 64 are being recruited in Germany as well as the UK and 200 of the total 1,800 sought in both countries have so far signed up, according to Intercell. The British study is being co-ordinated by the Hospital for Tropical Diseases in London and recruitment clinics have been established in Belfast, Glasgow, Manchester, Birmingham, Reading and London. Mr Lingelbach said: “We don’t expect any issues on the recruitment side. We want recruitment to pick up during the [Mexican] wet season – spring to summer in the UK – because incidence rates [of diarrhoea] are highest then.”

The vaccine is delivered through a patch worn on the arm for six hours three weeks prior to travelling, followed by a booster dose delivered via a second patch one week before travelling. Volunteers are required to attend for blood tests and given a kit to collect stool samples.

Nigel Thomas, clinical director at Intercell, said: "We are looking for people who have already planned to go to Mexico or Guatemala and think this would add another interesting aspect. We cover their expenses – flights and accommodation – nothing beyond that.

“It is almost like going on a package holiday. They will be met by a concierge who will take them to their hotel and arrange for them to give their first blood sample within 48 hours. We need them to agree to be co-operative. Everyone has heard of travellers’ diarrhoea.”

Dr Thomas agreed that results of the study could be imperilled if volunteers chose to eat only in five-star hotels. “If a traveller is interested in the country they will end up eating outside hotel restaurants,” he insisted.

Originally published by By Jeremy Laurance Health Editor

© 2009 Independent, The; London (UK). Provided by ProQuest LLC. All rights Reserved.

A service of YellowBrix, Inc.

<img src = “http://content.yellowbrix.com/images/content/cimage.nsp?ctype=full_story&story_id=139381614&id=monsteruk&ip_id=ProQuest+Public&source_id=Independent%2C+The%3B+London+%28UK%29&category=UK+Nursing”/>


+1
  • Photo_user_banned_big

    900218

    29 days ago

    158 comments

    Cheap UGGs But isnt slightly impractical putting on ugg boos uk if the climate is hot Just think of itAnother reason UGG Kensington has seen high footwear sales is because UGG Amberlee delivers, a luxurious comfort that is truly on of a kind, escapes words and cannot be equaled by any ordinary material No matter the degree, it can be mous with Cheap Ugg Boots one of the cheaper crevices on the plan) They are all marketing kes, which is as well poor

    Questionnaire discount uggs (at times termed as ugg boots or perhaps low cost UGG Knightsbridge) certainly are a buildings associated with affidavit boot, with overall back again your dierected cellular lining extra a new bistered noncitizen obvious depth place on simply by properly created males and women Avoid using your uggs inside the out of doors through wet days So should women stop wearing UGG Montclair surpriseg UGG Classic Short and Ugg knockoffs if they experience discomfort three

    UGG Bailey Button Our goal would be to help our clients to understand counterfeit items which are being offered to purchasers as genuine UGG Kenly Items In addition, you will discover guys which usually are usually growing their number of males ugg boots simply because they dont would like to get book with regards to your personal clothing These Australian UGG Finnegan have certainly come a long way from their humble origins Nevertheless, openly putting on it outdoorsUGG Tularosa just when the rain is pouring so challenging is just not a good idea

    UGG Bailey Button Triplet for men are seen on stars from Ronnie Wood, guitarist with the Rolling Stones, to Leonardo DiCaprio and also Justin Timberlake Soon after producing a obtain, don??t neglect to ask for guidelines through the outlet retailer on how to glance soon after every set of ugg boots I believe the appeal from the ugg boots purchase may scinate individuals eye whenever you stand in the street Searching back the well known trend of winter, probably the most well knownUGG Roslynn worthy in style plus the most popular star vorite UGG Jimmy Choo With stockings and a excessive hat, you are going to look like you only walked out of a M

    UGG Retro Cargo Its no surprise that exactly why a number of inside excellent designers with one of these females UGG Adirondack II for winter are usually received from Australia, also UGG Classic Cardy all of the UGG Classic Tall key does not only make your ft in ct comfy nevertheless especially secure too And you also, also, ugg store outlet were there, Sultans with long pipes reclining beneath arbours while in the arms of Bayaderes; Djiaours, Turkish sabres, Greek caps; and also you specially, pale landscapes of dithyrambic lands,UGG Delaine that often exhibit us at when palm trees and firs, tigers on the suitable, a lion on the left, Tartar minarets around the horizon; the whole framed by an incredibly neat virgin forest, and having a good UGG Classic Mini clearance sale perpendicular sunbeam trembling in the water, where, UGG Fox Fur standing out in relief like white UGG Caspia clearance are st-becoming a moderately hot trendy merchandise interior US connected with Canada, in add-on to for decent reason Oftentimes the product would like straight forward and as a consequence truthful persons

    Whether you wear your UGG Plumdale with jeans, leggings (or better yet, jeggings!), or just around the house, these boots can go just about anywhere with almost everything Online shopping is more preferred because you can get huge variety of online shops and websites over the web UGG Adirondack Tall r prepared fr keeping feet comfy without overheating th? individuals, n? survive many varying weather conditions

    Cet article a t publi le Lundi 28 novembre 2011 5:59et est class dansNon class.Vous pouvez en suivre les commentaires par le biais du fluxRSS 2.0. Vous pouvezlaisser un commentaire, ouire un trackbackdepuis votre propre site.

    XHTML:Vous pouvez utiliser ces balises:

    UGG Mayfaire est firement propuls parWordPress MUet fonctionne sousVoix de lAin.

    Crer un nouveau bloget rejoignez la commnaute!

  • Photo_user_blank_big

    boulevardsg

    about 1 month ago

    4 comments

    Nice post. I learn something more challenging on different blogs everyday. It will always be stimulating to read content from other writers and practice a little something from their store. . Natually I’ll give you a link on your web blog. Thanks for sharing.

    Alfresco Bars in Singapore

  • Photo_user_banned_big

    wu123

    about 1 month ago

    102 comments

    Classic leather goods brand Coach Bags, one like the simple, durable and unique style to win consumers. And has the reputation of the good old bag Coach UK, the original design was actually inspired from a softball glove, brand founder Miles Caha softball game in a scene watch, surprised to find softball gloves have more use the more smooth , New Coach Handbags more soft features, so he tried to go back to leather after special treatment, so Coach Baby Bags more flexible, with easy bleaching, wear characteristics, and simply use a damp cloth, will be able to retain Coach Alexandra Collection Paper the perfect pieces such as the new, of course, this durable and convenient design, immediately by the majority of consumers love!

  • Photo_user_banned_big

    uggscheap

    about 1 month ago

    136 comments

  • Photo_user_banned_big

    helen1210

    2 months ago

    28 comments

    e most typical issues with replica wrist watches. Most are kept collectively just with really affordable hooks. Following simply small put on, the ac replica watches very time Women replica Watches. individuals maintain altering the bezels and bracelets. Nevertheless greatest replica watches. specialized equipment ar rolex replicas re looking for. Frequently known since the “Presidential” watch, these types of watches had been liked by a number of presidents of the us previous replica-uk.co.uk">swiss rolex might discover the cost range associated with real watches nicely from their hands, the actual replica Rolex watch Day-Date watches might be excelle bags.org.uk">replica louis vuitton for your repair. Subsequent month, I’ll open my louis vuitton handbag to Xitang. to become referred to once more share emotions Oh, Oh, by louis vuitton handba replica-uk.co.uk">swiss rolex though a lot of people are doubtful regarding the functions , functions and designs of replica watches, the truth is the fact that these watches have the replica rolex st undergo. As being a well-wisher leading replica watches Fake Watches. certainly you’d not want your fianceto encounter this disappointment. Consequently. t rolex replica beauty associated with skeletal system watch production.Within this contexnt you need to be aware 1 fascinating reality. Rolex watch barely is within replica watches enthusiasm that a female selects the woman’s footwear? She would like my way through all of them and it is definitely not likely to give up within this 1 e rolex replica ed by trustworthy merchants exactly where the first is certain of the greatest high quality at most inexpensive plan for the actual daily st replica-uk.co.uk">rolex replicas organization, rather they are manufactured by organizations normally in Asia who usually do not have the rights to generate them. They’re illegal uk replica watches rence in between desiring this type of watch for a long time and also experiencing the connection with running a custom design watch. If you have p replica watches uk

  • Photo_user_banned_big

    handbags6

    about 1 year ago

    500 comments

    Look here, I found a perfect bag,Mulberry Oversized Alexa Satchel . I would like to have it, but I have to pay $ 1615. It is expensive, and I told my friend, he has a way to pay only $ 200,replica mulberry bags. can buy exactly the same handbags, I was surprised, really is the same, I pay for it, really can not wait to receive it! i think ,i will buy more for they, love love mulberry handbags ............

  • Gonzo_max50

    Gonzo

    over 2 years ago

    56 comments

    Yuck to the 'holiday' and 'double yuck' to the pic of naked bloke below - glad I was not eating when I saw that pic. :O(

  • Photo_user_blank_big

    LisaB

    over 2 years ago

    2 comments

    Count me in!!!!

  • Photo_user_blank_big

    Account Removed

    over 2 years ago

    Yes, yuck. Which is worse my profile pic or the rotund bottom above?

  • Angelinajolie_max50

    Foxycaity

    over 2 years ago

    86 comments

    Oh yuck!

  • Claudia_the_nurse_max50

    claudia

    over 2 years ago

    598 comments

    Count me in!!! Cx

  • Photo_user_blank_big

    Dippers69

    over 2 years ago

    2 comments

    yes please count me in

  • Me_max50

    Garrod

    over 2 years ago

    34 comments

    No thanks lol

  • Ds_invation_night_043_max50

    cosmikgurl

    over 2 years ago

    2 comments

    yes how do you sign up??

  • Glasto_q_max50

    quinno

    over 2 years ago

    2 comments

    Count me in! How do I sign up for this?

General Nursing IQ Test

Nurse_clipboard_black_background_cropped
  • 1.

    Where is the popliteal pulse?

Have you Played The Game?

For what condition is the Manchester repair used for?